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Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
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Effect of polyphenols on HER2-positive breast cancer and related miRNAs: Epigenomic regulation

María Eléxpuru Zabaleta1, Tamara Yuliett Forbes-Hernández2, Jesus Simal-Gandara3

  • 1Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Via Tronto 10/A, Torrette di Ancona, 60126 Ancona, Italy.

Food Research International (Ottawa, Ont.)
|November 25, 2020
PubMed

Insights

Dietary polyphenols show promise in treating HER2-positive breast cancer by modulating microRNAs. These natural compounds may reduce tumor growth and restore chemosensitivity without adverse effects.

Area of Science:

  • Oncology
  • Nutritional Science
  • Molecular Biology

Background:

  • HER2-positive breast cancer is an aggressive subtype with poor prognosis and therapy resistance.
  • Dietary polyphenols possess epigenetic regulatory properties beneficial for cancer prevention.
  • MicroRNAs play a critical role in regulating genes involved in tumor development.

Purpose of the Study:

  • To investigate the potential of dietary polyphenols as a therapeutic strategy for HER2-positive breast cancer.
  • To explore the role of polyphenols in modulating microRNA expression in this cancer subtype.
  • To assess the impact of polyphenols on tumor growth, metastasis, and chemosensitivity.

Main Methods:

  • Review of existing evidence on dietary polyphenols and their interaction with microRNAs in HER2-positive breast cancer.
  • Analysis of studies demonstrating polyphenol-mediated epigenetic regulation.
  • Examination of clinical trial data and preclinical research on polyphenol efficacy.

Main Results:

  • Dietary polyphenols modulate specific microRNAs associated with HER2-positive breast cancer.
  • Polyphenols demonstrate a reduction in tumor growth and metastatic potential.
  • Polyphenols can restore chemosensitivity to conventional therapies without significant toxicity.

Conclusions:

  • Dietary polyphenols represent a promising therapeutic avenue for HER2-positive breast cancer.
  • Polyphenols may be utilized as a complementary or alternative treatment, alone or with standard therapies.
  • Further clinical investigation into polyphenols is warranted for HER2-positive breast cancer patients.
Keywords:
Antitumorigenic activityChemoresistanceErbB2Low toxicityMediterranean dietPreventiononcomiRtumor suppressor miR

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