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Home-Based Transcranial Direct Current Stimulation Device Development: An Updated Protocol Used at Home in Healthy Subjects and Fibromyalgia Patients
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Low Intensity, Transcranial, Alternating Current Stimulation Reduces Migraine Attack Burden in a Home Application

Andrea Antal1, Rebecca Bischoff1, Caspar Stephani1

  • 1Department of Clinical Neurophysiology, University Medical Center, Georg-August University, 37075 Göttingen, Germany.

Brain Sciences
|November 25, 2020
PubMed
Summary

Transcranial alternating current stimulation (tACS) may terminate migraine attacks. Active tACS showed a higher success rate than placebo, but study complexity led to high dropout rates.

Keywords:
acute treatmentmigrainetACStranscranial stimulationvisual cortex

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Area of Science:

  • Neurology
  • Neuroscience
  • Medical Devices

Background:

  • Transcranial alternating current stimulation (tACS) at low intensity and high frequency over the motor cortex is known to reduce motor evoked potentials.
  • Migraine management is an area of significant unmet need.

Purpose of the Study:

  • To evaluate the efficacy of home-based, visual cortex tACS for the acute management of migraine attacks.
  • To determine if tACS can terminate migraine attacks without the need for rescue medication.

Main Methods:

  • A double-blind, placebo-controlled, parallel-group study involving 40 patients.
  • Patients received either active (0.4 mA, 140 Hz) or sham tACS for 15 minutes over the visual cortex.
  • The primary endpoint was the number of terminated attacks within two hours post-stimulation, with a maximum of five attacks treated over six weeks.

Main Results:

  • Twenty-five patients completed the study (16 active, 9 sham).
  • Migraine attacks terminated without rescue medication occurred in 21.5% of active treatments versus 0% of sham treatments.
  • Active tACS resulted in significantly less perceived pain for 2-4 hours post-stimulation compared to sham.

Conclusions:

  • Visual cortex tACS demonstrates potential for terminating migraine attacks.
  • The complexity and time-consuming setup of tACS present significant barriers to patient compliance and widespread adoption.