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Integrative p53, micro-RNA and Cathepsin Protease Co-Regulatory Expression Networks in Cancer

Surinder M Soond1, Maria V Kozhevnikova2, Paul A Townsend3

  • 1Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Trubetskaya str. 8-2, 119991 Moscow, Russia.

Cancers
|November 25, 2020
PubMed

Insights

The tumor suppressor p53 and micro-RNAs regulate cathepsin gene expression, impacting cancer. These micro-RNAs show promise as diagnostic and prognostic biomarkers.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Genetics

Background:

  • The tumor suppressor p53 plays a crucial role in gene expression regulation.
  • Micro-RNAs (miRNAs) are key regulators of gene expression, particularly in cancer.
  • Cathepsin proteases are implicated in normal cellular homeostasis and cancer progression.

Purpose of the Study:

  • To review the interplay between p53 and micro-RNA transcriptional regulation.
  • To highlight micro-RNAs that regulate cathepsin proteases.
  • To explore the potential of these micro-RNAs as diagnostic and prognostic biomarkers.

Main Methods:

  • Literature review of studies on p53, micro-RNAs, and cathepsins.
  • Analysis of the mechanistic links between p53-regulated micro-RNAs and cathepsin gene expression.
  • Discussion of current and future clinical applications.

Main Results:

  • Established regulatory role of p53 in gene expression.
  • Significant interest in the interplay between p53 and micro-RNA transcriptional regulation.
  • Identification of specific p53-regulated micro-RNAs that target cathepsin proteases.

Conclusions:

  • The p53-micro-RNA axis significantly influences cathepsin gene expression.
  • p53-regulated micro-RNAs targeting cathepsins offer potential as cancer biomarkers.
  • Further research is needed to fully elucidate these mechanisms and their clinical utility.
Keywords:
cancercathepsinmiRNAmicro-RNAp53

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