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Antimicrobial Proteins

Antimicrobial Proteins

Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...

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Related Experiment Video

Updated: Nov 28, 2025

Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization

Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization

Published on: August 11, 2018

Structural and Functional Enrichment Analyses for Antimicrobial Peptides.

Sheng C Lo¹, Zhong-Ru Xie², Kuan Y Chang¹

¹Computational Biology Laboratory, Department of Computer Science and Engineering, National Taiwan Ocean University, Keelung 202, Taiwan.

International Journal of Molecular Sciences

|November 25, 2020

Summary

Antimicrobial peptides (AMPs) show structure-function inclinations. Antifungal AMPs associate with specific structures, while antibacterial AMPs link to TM Cluster 3, aiding new therapeutic design.

Keywords:

antifungal activities enrichment analysis knottin structure–function relationships two-layer sandwich architecture

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Last Updated: Nov 28, 2025

Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization

Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization

Published on: August 11, 2018

Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group

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Published on: August 16, 2017

Semi-Quantitative Analysis of Peptidoglycan by Liquid Chromatography Mass Spectrometry and Bioinformatics

Semi-Quantitative Analysis of Peptidoglycan by Liquid Chromatography Mass Spectrometry and Bioinformatics

Published on: October 13, 2020

Area of Science:

Biochemistry
Structural Biology
Computational Biology

Background:

Antimicrobial peptides (AMPs) possess diverse structures and broad-spectrum antimicrobial functions.
The relationship between AMP structure and specific antimicrobial activity remains largely unexplored.
Existing research lacks clear links between structural classifications and functional tendencies of AMPs.

Purpose of the Study:

To investigate potential structure-function relationships in antimicrobial peptides (AMPs).
To identify specific structural features associated with distinct antimicrobial activities using enrichment analysis.
To provide insights for designing novel AMPs with therapeutic potential.

Main Methods:

Utilized enrichment analysis to examine AMPs.
Classified AMP structures using CATH, SCOP, and TM structural classification databases.
Correlated structural categories with seven distinct antimicrobial functions (antibacterial, antifungal, etc.).

Main Results:

Antifungal activity in AMPs significantly correlated with CATH's two-layer sandwich structure, SCOP's knottin fold, and TM's first structural cluster.
These structure-function associations, particularly with knottin and TM Cluster 1, persisted even in AMPs with low sequence identity.
A notable enrichment was found between TM's third cluster and activities against Gram-positive and Gram-negative bacteria.

Conclusions:

Demonstrated specific structure-function inclinations within antimicrobial peptides.
Highlighted key structural motifs associated with antifungal and antibacterial activities.
Findings support the rational design of novel AMPs for therapeutic applications.