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Treating Coronary Artery Disease: Beyond Statins, Ezetimibe, and PCSK9 Inhibition

Kiran Musunuru1

  • 1Cardiovascular Institute, Department of Medicine, Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;

Annual Review of Medicine
|November 25, 2020
PubMed

Insights

New therapies targeting lipid traits and inflammation show promise for preventing and treating coronary artery disease, a leading cause of death. Advances in human genetics are driving the development of these innovative treatments.

Area of Science:

  • Cardiovascular Medicine
  • Genetics
  • Pharmacology

Background:

  • Coronary artery disease (CAD) remains a primary global cause of mortality despite current standard treatments like statins, ezetimibe, and PCSK9 inhibitors.
  • The persistent burden of CAD necessitates the exploration and development of novel therapeutic strategies.
  • Recent advancements in human genetics have opened new avenues for understanding and targeting CAD pathogenesis.

Purpose of the Study:

  • To review emerging therapies for coronary artery disease.
  • To highlight the role of genetic insights in developing new treatments.
  • To discuss the potential impact of novel therapies on patient care.

Main Methods:

  • Review of recent clinical trials and regulatory approvals.
  • Analysis of new therapeutic targets including lipid traits and inflammation.
  • Synthesis of information from human genetics research.

Main Results:

  • Several new therapies targeting lipid metabolism and inflammatory pathways have been approved or shown promise in clinical trials.
  • Advances in human genetics have identified novel targets for cardiovascular disease intervention.
  • These emerging treatments offer potential improvements over existing therapies for CAD patients.

Conclusions:

  • New therapies informed by genetic discoveries are poised to significantly alter the management of coronary artery disease.
  • The pipeline of novel treatments offers hope for reducing mortality associated with CAD.
  • Personalized medicine approaches, guided by genetic insights, may enhance the efficacy of future CAD therapies.

Keywords:
cholesterolcoronary artery diseasegeneticsinflammationlipoproteinstriglycerides

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