Microvesicles-mediated Cell Communication in Pulmonary Arterial Hypertension
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Published on: May 21, 2018
Lei Chen1, Ying-Jian Gu1, Ming-Yuan Zhou1
1Department of Clinical Pharmacology, School of Pharmacy, China Medical University, Shenyang, Liaoning110122, China.
Background:
Pulmonary arterial hypertension is one of the chronic diseases that affect human health. Microvesicles participate in the communication between cells by fusing with the recipient cells to transfer the bioactive molecules, such as lipids, proteins, RNA, etc., to the target cells. Microvesicles are involved in various biological processes and have the functions of regulating immunity, promoting angiogenesis, and so on. Microvesicles derived from various cells may become the diagnostic biomarkers or therapeutic targets for the diseases. Therefore, exploring the role of microvesicles-mediated cell communication has become a potential therapeutic target for pulmonary arterial hypertension.
Objective:
It is to clarify the classification, features, and mechanism of microvesicles in cell communication and to discuss the potentially important roles of microvesicles-mediated cell communication in pulmonary arterial hypertension.
Results:
Inflammation is an important pathogenesis of pulmonary arterial hypertension. Many studies have shown that microvesicles from different cells can participate in the pathological process of pulmonary arterial hypertension by transferring the inflammatory factors contained in them.
Conclusion:
Microvesicles-mediated cell communication may become the therapeutic target for pulmonary arterial hypertension.
Insights
Microvesicles mediate cell communication and are implicated in pulmonary arterial hypertension pathogenesis. Targeting microvesicle communication offers a potential therapeutic strategy for this chronic lung disease.
Area of Science:
- Cellular Biology
- Biomedical Science
- Pathophysiology
Background:
- Pulmonary arterial hypertension (PAH) is a chronic disease impacting human health.
- Microvesicles facilitate intercellular communication by transferring bioactive molecules, influencing immunity and angiogenesis.
- Microvesicles are explored as diagnostic biomarkers and therapeutic targets for diseases like PAH.
Purpose of the Study:
- To elucidate the classification, features, and mechanisms of microvesicle-mediated cell communication.
- To investigate the role of microvesicle communication in the context of pulmonary arterial hypertension.
Main Methods:
- Literature review on microvesicle function and PAH.
- Analysis of studies detailing microvesicle involvement in cellular processes.
- Examination of research on microvesicles in inflammatory pathways.
Main Results:
- Inflammation is a key factor in PAH development.
- Microvesicles derived from various cells contribute to PAH pathology by transferring inflammatory factors.
- Microvesicle-mediated transfer of inflammatory mediators plays a role in PAH progression.
Conclusions:
- Microvesicle-mediated cell communication is integral to PAH.
- Targeting microvesicle communication presents a promising therapeutic avenue for pulmonary arterial hypertension.
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