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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Treatment Resistant Cancers02:56

Treatment Resistant Cancers

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
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Cancer02:18

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Related Experiment Video

Updated: Nov 28, 2025

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
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Developing Novel Anticancer Drugs for Targeted Populations: An Update.

Tadesse B Tafesse1, Mohammed H Bule1, Fazlullah Khan2

  • 1Department of Medicinal Chemistry, School of Pharmacy, Drug Design and Development Research Center and The Institute of Pharmaceutical Sciences, Tehran University of Medical Sciences, Tehran, Iran.

Current Pharmaceutical Design
|November 25, 2020
PubMed
Summary

Drug repurposing accelerates the development of novel anticancer drugs, offering a faster and more cost-effective alternative to traditional de novo discovery. This strategy enhances the success rate for targeted cancer therapies.

Keywords:
Anticancer drugscancerdrug developmentdrug discoverydrug repurposingplerixafortargeted populationthalidomide

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Area of Science:

  • Oncology
  • Pharmacology
  • Drug Development

Background:

  • Traditional de novo drug discovery is lengthy, costly, and has high failure rates, slowing the delivery of new cancer drugs.
  • Pediatric cancer patients face particular challenges in accessing novel, safe, and effective treatments.

Purpose of the Study:

  • To explore the development of novel anticancer drugs.
  • To focus on identifying and selecting targeted drug development strategies for specific patient populations.

Main Methods:

  • A comprehensive literature review was conducted.
  • Databases searched included PubMed, SCOPUS, Web of Science, and EMBASE using various keywords.

Main Results:

  • Drug repurposing is an alternative strategy that significantly reduces development time (3-12 years) and cost compared to de novo discovery (10-17 years).
  • Drug repurposing offers a higher probability of success (approx. 25%) compared to de novo discovery (less than 10%).

Conclusions:

  • Identifying and selecting specific molecular targets is crucial for advancing novel anticancer drug development.
  • Drug repurposing is an influential strategy for discovering and developing new anticancer drug candidates, considering patient age and disease stage.