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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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Role of Hydrogen in Atherosclerotic Disease: From Bench to Bedside

Shucun Qin1

  • 1The Institute of Atherosclerosis and Taishan Institute for Hydrogen Biomedicine, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian 271000, China.

Current Pharmaceutical Design
|November 25, 2020
PubMed

Insights

Hydrogen may help prevent and treat atherosclerosis, a major cause of heart and brain disease. Research shows its antioxidant and anti-inflammatory properties are key to its anti-atherosclerotic effects in studies.

Area of Science:

  • Biomedical Science
  • Cardiovascular Research
  • Molecular Medicine

Background:

  • Atherosclerosis (AS) is a leading global cause of death.
  • Cardiovascular and cerebrovascular diseases are major health concerns.
  • Hydrogen is recognized for its antioxidant and anti-inflammatory properties.

Purpose of the Study:

  • To review the role of hydrogen in preventing and treating atherosclerosis.
  • To summarize pathophysiological characteristics and risk factors of AS.
  • To analyze laboratory and human study data on hydrogen's anti-atherosclerotic effects.

Main Methods:

  • Literature review of over 50 English-language publications.
  • Analysis of animal models and human studies on hydrogen and AS.
  • Examination of molecular mechanisms of hydrogen's efficacy.

Main Results:

  • Evidence suggests hydrogen possesses anti-atherosclerotic properties.
  • Studies in animal models and humans indicate potential benefits.
  • Molecular mechanisms underlying hydrogen's efficacy are being explored.

Conclusions:

  • Hydrogen shows promise as a therapeutic agent for atherosclerosis.
  • Further research, including larger clinical trials, is warranted.
  • Deeper investigation into molecular mechanisms is needed for optimal treatment strategies.

Keywords:
Atherosclerosiscardiovascular diseasesefficacy responsehydrogenoxidative stresspreventiontreatment

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