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Is the Mean Platelet Volume a Predictive Factor for Atrial Fibrillation Developing After Coronary Artery Bypass
Arda Aybars Pala1, Yusuf Salim Urcun2
1Department of Cardiovascular Surgery, Adiyaman Training and Research Hospital, Adiyaman, Turkey. ardaaybars@hotmail.com.
Insights
Elevated preoperative mean platelet volume (MPV) is linked to increased risk of postoperative atrial fibrillation (PoAF) after coronary artery bypass grafting (CABG) in elderly patients. This finding highlights MPV as a potential predictor for PoAF development.
Area of Science:
- Cardiology
- Geriatric Medicine
- Hematology
Background:
- Postoperative atrial fibrillation (PoAF) is a common complication after coronary artery bypass grafting (CABG), particularly in elderly individuals.
- Mean platelet volume (MPV) is an indicator of platelet activation, inflammation, and thrombotic processes.
Purpose of the Study:
- To investigate the association between preoperative mean platelet volume (MPV) levels and the incidence of PoAF in elderly patients undergoing isolated CABG.
Main Methods:
- A cohort of 103 elderly patients (≥ 65 years) in preoperative sinus rhythm undergoing isolated CABG was studied.
- Patients were divided into two groups: those who developed PoAF (N=29) and those who did not (N=74).
- Preoperative MPV levels were compared between the groups, and multivariate logistic regression was used to identify independent predictors of PoAF.
Main Results:
- The incidence of PoAF was 28.2%.
- Preoperative MPV levels were significantly higher in patients who developed PoAF (9.28 ± 1.00 fL) compared to those who did not (8.41 ± 1.13 fL) (P < .001).
- Independent predictors for PoAF included age, preoperative hemoglobin, and preoperative MPV (OR: 2.103, P = .002). The MPV cut-off value for predicting PoAF was 8.43 fL.
Conclusions:
- Preoperative mean platelet volume (MPV) is significantly associated with the development of postoperative atrial fibrillation (PoAF) in elderly patients undergoing CABG.
- Age and preoperative hemoglobin levels are also independent predictors of PoAF development in this patient population.
Background:
Postoperative atrial fibrillation (PoAF) is the most common arrhythmic complication detected after coronary artery bypass grafting (CABG). It is associated with increased morbidity and mortality, especially in elderly patients. Mean platelet volume (MPV) shows the activation of platelets effective in the inflammatory and thrombotic process. The purpose of the present study was to investigate the relations between the preoperative MPV levels and development of PoAF in isolated CABG in elderly patients.
Methods:
A total of 103 elderly patients (aged ≥ 65 years), who underwent isolated CABG and were at preoperative sinus rhythm, were included in the study. Patients who did not have PoAF were identified as Group 1 (N = 74), and those with PoAF were identified as Group 2 (N = 29).
Results:
PoAF incidence was 28.2%. Preoperative MPV level was 8.41 ± 1.13 fL in Group 1, and 9.28 ± 1.00 fL in Group 2. The difference was statistically significant (P < .001). Multivariate logistic regression analysis revealed that age, preoperative hemoglobin, and preoperative MPV were independent predictive factors for PoAF development (OR [odds ratio]: 1.149, 95% CI [confidence interval]: 1.043-1.265, P = .005; OR: 1.334, 95% CI: 1.013-1.758, P = .040; OR: 2.103, 95% CI: 1.324-3.339, P = .002, respectively). The cut-off value for MPV as the predictor of PoAF development was found to be 8.43 (sensitivity: 82.8% and specificity: 55.4%).
Conclusion:
This study showed that MPV levels are associated with PoAF development in elderly patients, and other independent predictive factors include age and preoperative hemoglobin levels for POAF development.
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