Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Teratogenicity01:07

Teratogenicity

3.8K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: Advancing treatments for protozoan diseases: from resistance mechanisms to novel therapies.

Frontiers in microbiology·2026
Same author

BKI-1748 confers a high level of protection against ovine congenital toxoplasmosis when administered after IgM seroconversion.

Frontiers in cellular and infection microbiology·2026
Same author

Ovine macrophage identity and plasticity: novel insights into CSF-driven polarization and species-specific responses.

Frontiers in immunology·2025
Same author

Pleiotropic Effects on Tachyzoite and Host Cell Proteomes in Knock-Out Clones of the Open Reading Frames 297720 and 319730 Constitutively Expressed in <i>T. gondii</i> ShSp1 Tachyzoites.

International journal of molecular sciences·2025
Same author

Proteome changes during <i>in vitro</i> culture adaptation of <i>Toxoplasma gondii</i> archetypal II and III field isolates.

Frontiers in cellular and infection microbiology·2025
Same author

Fatal Toxoplasma gondii COUG strain infections in southern sea otters (Enhydra lutris nereis): New insight on contributing factors and parasite serotyping.

PloS one·2025

Related Experiment Video

Updated: Nov 28, 2025

Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-&#947;-Dependent Cell Autonomous Immunity
11:21

Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-γ-Dependent Cell Autonomous Immunity

Published on: March 12, 2015

11.3K

Toxoplasma Effectors that Affect Pregnancy Outcome.

David Arranz-Solís1, Debanjan Mukhopadhyay1, Jeroen J P Saeij1

  • 1Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.

Trends in Parasitology
|November 25, 2020
PubMed
Summary

Toxoplasma gondii manipulates host cell signaling in the placenta, creating a conflict between clearing the infection and preventing pregnancy loss. Understanding these mechanisms is crucial for managing parasitic infections during gestation.

Keywords:
GRAROPToxoplasmagestationplacenta

More Related Videos

Genetic Manipulation in &Delta;ku80 Strains for Functional Genomic Analysis of Toxoplasma gondii
09:52

Genetic Manipulation in Δku80 Strains for Functional Genomic Analysis of Toxoplasma gondii

Published on: July 12, 2013

17.4K
QTL Mapping and CRISPR/Cas9 Editing to Identify a Drug Resistance Gene in Toxoplasma gondii
11:37

QTL Mapping and CRISPR/Cas9 Editing to Identify a Drug Resistance Gene in Toxoplasma gondii

Published on: June 22, 2017

16.6K

Related Experiment Videos

Last Updated: Nov 28, 2025

Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-&#947;-Dependent Cell Autonomous Immunity
11:21

Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-γ-Dependent Cell Autonomous Immunity

Published on: March 12, 2015

11.3K
Genetic Manipulation in &Delta;ku80 Strains for Functional Genomic Analysis of Toxoplasma gondii
09:52

Genetic Manipulation in Δku80 Strains for Functional Genomic Analysis of Toxoplasma gondii

Published on: July 12, 2013

17.4K
QTL Mapping and CRISPR/Cas9 Editing to Identify a Drug Resistance Gene in Toxoplasma gondii
11:37

QTL Mapping and CRISPR/Cas9 Editing to Identify a Drug Resistance Gene in Toxoplasma gondii

Published on: June 22, 2017

16.6K

Area of Science:

  • Immunology
  • Parasitology
  • Reproductive Biology

Background:

  • The placenta is an immune-privileged site, typically tolerating foreign antigens.
  • Controlling intracellular pathogens like Toxoplasma requires a Th1 immune response, involving interferon-gamma.
  • This necessary immune response risks triggering abortion in the placenta.

Purpose of the Study:

  • To explore how Toxoplasma gondii strain type and effector proteins influence host cell signaling pathways.
  • To speculate on the impact of these interactions on pregnancy outcomes.

Main Methods:

  • Review of existing literature on Toxoplasma-host interactions in placental cells.
  • Analysis of host cell signaling pathways affected by parasite effectors.
  • Speculative discussion based on current knowledge.

Main Results:

  • Toxoplasma gondii employs specific strain types and effector proteins.
  • These effectors modulate host cell signaling pathways within the placenta.
  • The modulation creates a complex immune environment during infection.

Conclusions:

  • Toxoplasma gondii infection presents a significant challenge to maintaining pregnancy.
  • Parasite manipulation of placental immunity is key to its success and potential to cause abortion.
  • Further research into parasite effectors and host signaling is needed to understand and potentially mitigate adverse pregnancy outcomes.