Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

3.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
3.8K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

1.6K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.6K
Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

2.0K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.0K
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

3.3K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
3.3K
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

566
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
566
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

3.2K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From Resuscitation to Rehabilitation: The Post-Intensive Care Syndrome Continuum in Sepsis Care.

Journal of clinical medicine·2025
Same author

Evaluation of the Modified Early Warning Score (MEWS) in In-Hospital Cardiac Arrest in a Tertiary Healthcare Facility.

Journal of clinical medicine·2025
Same author

Overview and management of hepatorenal syndrome.

Current opinion in anaesthesiology·2025
Same author

Sepsis Care: Cardiovascular Challenges and Solutions for Nurses.

Critical care nursing quarterly·2025
Same author

Racial Disparities in Septic Shock Outcomes: A Nationwide Analysis (2016-2020).

Journal of general internal medicine·2025
Same author

COVID-19-related Pneumonitis in Immunocompromised Patients: Reviewing Clinical Features and Management Approaches.

Journal of community hospital internal medicine perspectives·2024
Same journal

The Relationship Between Ethical Ideology and Moral Resilience in Critical Care Nurses.

Critical care nursing quarterly·2026
Same journal

The Effect of Monitor Alarm Management Training on the Level of Alarm Fatigue of Nurses in Intensive Care Units.

Critical care nursing quarterly·2026
Same journal

Oral Care in Patients With Invasive Airway Management in the ICU: A Prospective Observational Study.

Critical care nursing quarterly·2026
Same journal

Nurses' Perceived Barriers to the Implementation and Sustainability of Best Patient Safety in Handover in the Clinical Setting: Cross-Sectional Survey Study.

Critical care nursing quarterly·2026
Same journal

Association Between Early Tracheostomy and Patient Outcomes in Critically Ill Patients on Mechanical Ventilator: A Retrospective Cohort Study.

Critical care nursing quarterly·2026
Same journal

Nurses' Knowledge of Blood Transfusion Safety at Intensive Care Units in Jordan: A Cross-Sectional Study.

Critical care nursing quarterly·2026
See all related articles

Related Experiment Video

Updated: Nov 28, 2025

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD
04:03

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD

Published on: September 27, 2024

1.1K

Pathophysiology of COPD.

Jennifer Leap1, Obaid Arshad, Tariq Cheema

  • 1Division of Pulmonary Critical Care Medicine, Allegheny Health Network, Allegheny General Hospital, Pittsburgh, Pennsylvania.

Critical Care Nursing Quarterly
|November 25, 2020
PubMed
Summary
This summary is machine-generated.

This article explains chronic obstructive pulmonary disease (COPD) pathophysiology, covering physiological precursors, environmental and genetic causes, and the role of alpha1-antitrypsin deficiency in airflow obstruction.

More Related Videos

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

11.3K
Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders
05:34

Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders

Published on: August 18, 2023

3.0K

Related Experiment Videos

Last Updated: Nov 28, 2025

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD
04:03

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD

Published on: September 27, 2024

1.1K
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

11.3K
Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders
05:34

Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders

Published on: August 18, 2023

3.0K

Area of Science:

  • Pulmonary Medicine
  • Respiratory Pathophysiology

Background:

  • Chronic obstructive pulmonary disease (COPD) is a major global health concern.
  • Understanding its complex pathophysiology is crucial for effective management.

Purpose of the Study:

  • To provide a comprehensive overview of COPD pathophysiology.
  • To discuss the physiological mechanisms underlying COPD development.
  • To examine the influence of environmental and genetic factors.

Main Methods:

  • Literature review of existing research on COPD.
  • Analysis of physiological mechanisms contributing to airflow obstruction.
  • Discussion of etiological factors including genetics and environment.

Main Results:

  • Identified key physiological precursors to COPD.
  • Highlighted the significant roles of environmental exposures and genetic predispositions.
  • Detailed the contribution of alpha1-antitrypsin deficiency to COPD pathogenesis.

Conclusions:

  • COPD arises from a complex interplay of physiological, environmental, and genetic factors.
  • Alpha1-antitrypsin deficiency is a specific genetic risk factor for airflow obstruction.
  • Further research into these areas can inform therapeutic strategies.