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Effect of hyperglycemia on all-cause mortality from pediatric brain injury: A systematic review and meta-analysis

Shuyun Chen1,2, Zhaohe Liu1,2

  • 1Department of Clinical Nutrition.

Medicine
|November 25, 2020
PubMed

Insights

Hyperglycemia significantly increases all-cause mortality risk in pediatric brain injury patients. Further large-scale studies are needed to confirm this association.

Area of Science:

  • Pediatric critical care medicine
  • Neurology
  • Endocrinology

Background:

  • Hyperglycemia is a common metabolic disturbance in critically ill children.
  • Brain injury in pediatric patients presents complex management challenges.
  • The impact of hyperglycemia on outcomes in pediatric brain injury remains incompletely understood.

Purpose of the Study:

  • To systematically review and meta-analyze the existing evidence on the association between hyperglycemia and all-cause mortality in pediatric patients with brain injury.

Main Methods:

  • Systematic literature search of PubMed, Embase, and Cochrane Library databases.
  • Inclusion of original observational studies assessing hyperglycemia and mortality in pediatric brain injury.
  • Meta-analysis using a fixed-effects model; risk of bias and publication bias assessment.

Main Results:

  • Nine observational studies with 970 pediatric patients (304 with hyperglycemia) were included.
  • Hyperglycemia was strongly associated with increased all-cause mortality (OR = 11.60, 95% CI 7.88-17.08).
  • No publication bias was detected, though study quality was generally low.

Conclusions:

  • Hyperglycemia is significantly linked to higher all-cause mortality in pediatric brain injury.
  • The findings highlight the critical importance of glycemic control in this vulnerable population.
  • Further robust research, including large-scale observational studies and RCTs, is warranted to confirm these results.
Abstract

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