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Relationship between digestive diseases and COVID-19 severity and mortality: A protocol for systematic review and
Jinjuan Li1, Jia Yue1, Shunan Zhang1
1School of Public Health, Gansu University of Chinese Medicine.
Insights
This study investigates if digestive diseases increase COVID-19 severity and death risk. Findings will clarify the link between gastrointestinal conditions and coronavirus outcomes.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Epidemiology
Background:
- Digestive diseases are frequently observed in COVID-19 patients.
- The impact of pre-existing digestive comorbidities on COVID-19 outcomes remains uncertain.
Purpose of the Study:
- To evaluate the association between digestive diseases and COVID-19 severity.
- To assess the relationship between digestive diseases and COVID-19 mortality.
Main Methods:
- Systematic literature search of multiple databases up to October 1, 2020.
- Meta-analysis using random-effects model with inverse variance method.
- Quality assessment using Newcastle-Ottawa scale and heterogeneity analysis.
Main Results:
- Results will be published in a peer-reviewed journal.
Conclusions:
- This study will provide comprehensive evidence on the association between digestive diseases and COVID-19 severity and mortality.
- Findings aim to support clinical practice and inform guidelines development.
Background:
Digestive diseases have been often reported in COVID-19 patients, but whether COVID-19 patients with existing digestive comorbidities are at an increased risk of serious disease and death remains unclear. This study aims to evaluate the association between digestive diseases and COVID-19 severity and mortality.
Methods:
PubMed, Embase.com, the Cochrane Central Register of Controlled Trials, Web of Science, China National Knowledge Infrastructure, Wanfang, and SinoMed will be searched to identify relevant studies up to October 1, 2020. We will use the Newcastle-Ottawa quality assessment scale to assess the quality of included studies. We will use Stata to perform pairwise meta-analyses using the random-effects model with the inverse variance method to estimate the association between digestive diseases and the mortality and severity of COVID-19. Subgroup analyses and sensitivity analyses will be conducted to investigate the sources of heterogeneity. We will create a "Summary of findings' table presenting our primary and secondary outcomes using the GRADEpro Guideline Development Tool software.
Results:
The results of this study will be published in a peer-reviewed journal.
Conclusions:
This study will comprehensively evaluate the association between digestive diseases and the severity and mortality of patients with COVID-19. The results of this study will provide high-quality evidence to support clinical practice and guidelines development.
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