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Colchicine in Dermatology: Rediscovering an Old Drug with Novel Uses
Kabir Sardana1, Surabhi Sinha1, Soumya Sachdeva1
1Department of Dermatology, STD and Leprosy, ABVIMS and Dr. Ram Manohar Lohia Hospital, New Delhi, India.
Abstract:
Colchicine is an anti-inflammatory agent which has been used for decades in the treatment of gout. The drug has a number of dermatological indications like Psoriasis, Sweet's syndrome, aphthosis, Behcet's disease, erythema nodosum, leukocytoclastic vasculitis and is consistently effective in neutrophilic disorders. Thought it is an affordable with minimal side effects, It has remained underutilized. However, it has novel uses and is being considered in COVID-19 due to its action on IL-1β and IL-6. This article presents a concise and up-to-date review focusing on its mechanisms of action and indications.
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