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Updated: Nov 28, 2025

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
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Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS

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Mathematical modeling of ventilator-induced lung inflammation

Sarah Minucci, Rebecca L Heise, Michael S Valentine

    Biorxiv : the Preprint Server for Biology
    |November 25, 2020
    PubMed
    Summary

    This study models the immune response to ventilation-induced lung injury (VILI), finding epithelial repair and macrophage polarization dynamics predict patient outcomes. This informs potential interventions for improving VILI recovery.

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