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IL 1 and bacterial lipopolysaccharide increase the ability of human endothelial cells to bind peripheral blood
E C Downs1, D G Cornwell, V K Proctor
1Department of Physiological Chemistry, Ohio State University 43210.
Lymphokine Research
|January 1, 1987
Abstract:
Human endothelial cells (EC) exposed to human recombinant IL 1 and to bacterial lipopolysaccharide (LPS) demonstrated a time dependent increase in their ability to bind peripheral blood monocytes (M0). The enhancement of endothelial-M0 interactions was shown to represent a direct alteration of EC and was not explained by IL 1 and LPS affecting M0. Other experiments indicated that the enhancement represented an acceleration in EC binding of M0 suggesting that EC may play a role in initiating proinflammatory events prior to the recruitment of inflammatory cells by chemotactic peptides.