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Beyond the Health Deficit Count: Examining Deficit Patterns in a Deficit-Accumulation Frailty Index
Brianne L Olivieri-Mui1, Sandra M Shi1,2, Ellen P McCarthy1,2
1The Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts, USA.
Background/Objectives:
Exploring deficit patterns among frail people may reveal subgroups of different prognostic importance.
Design:
Analysis of National Health and Aging Trends Study.
Setting:
Community.
Participants:
Community dwelling older adults with mild to moderate frailty (deficit-accumulation frailty index (FI) of 0.25-0.40) (n = 1821).
Measurements:
Latent class analysis identified distinct clinical subgroups based on comorbidity (range: 0-10), National Health and Aging Trends Study dementia classification, and short physical performance battery (SPPB) (range: 0-12). Survival analyses compared 5-year mortality by subgroups.
Results:
Three latent classes existed: Class 1 (n = 831, mean FI = 0.30) had 2.7% probable dementia, high comorbidities (mean = 3.6), and low physical impairment (SPPB mean = 9.9); Class 2 (n = 734, mean FI = 0.32) had 6.9% probable dementia, low comorbidities (mean = 2.8), and moderate physical impairment (SPPB mean = 6.2); Class 3 (n = 256, mean FI = 0.34) had 20.7% probable dementia, low comorbidities (mean = 2.4), and high physical impairment (SPPB mean = 2.0). Compared to Class 1, Classes 2 and 3 experienced higher 5-year mortality (C2: 1.28 (95% confidence intervals (CI) = 1.00-1.62); C3: 1.87 (95% CI = 1.29-2.73)).
Conclusion:
Deficit patterns among the mild-to-moderately frail provide additional prognostic information and highlight opportunities for preventive interventions.
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