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Synthetic methods for compounds containing fluoro-lactam units
Xin Wang1, Jia Lei, Guofeng Li
1School of Chemistry and Chemical Engineering, YanTai University, Yantai, 264005, Shandong, P. R. China. wangx933@nenu.edu.cn jiazhu82@ytu.edu.cn sunk468@nenu.edu.cn.
Abstract:
In recent years, considerable attention has been devoted to the exploration of novel synthetic methods for fluoro-lactams due to their significant biological and pharmaceutical activities. This review summarizes recently established strategies for synthesizing fluorine-substituted lactams, including fluoro-β-lactams, fluoro-γ-lactams, and fluoro-δ-lactams. Additionally, the reaction scopes, limitations, and mechanisms are discussed.

