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PREDICTIVE FACTORS FOR LOSS OF RESPONSE TO ANTI-TNF IN CROHN'S DISEASE
Byanca Rossetti Moreira Dos Santos1, Carlos Henrique Marques Dos Santos1,2, Vitória Rossetti Moreira Dos Santos1
1Department of Surgery, Regional Hospital Rosa Pedrossian, Campo Grande, MS, Brazil.
Background:
Anti-TNF drugs are a fundamental part of the treatment of Crohn's disease (CD), so identifying factors related to loss of response is of great importance in clinical practice.
Aim:
Identify potential factors related to loss of response to anti-TNF agents in Crohn's disease patients.
Methods:
This is a prospective study of CD patients attending a specialized outpatient clinic using a specific form, including patients with more than one year of follow-up on anti-TNF (Infliximab, Adalimumab or Certolizumab pegol). The information obtained was tabulated and analyzed to identify possible reasons for the loss of response to anti-TNF agents; results were submitted to statistical analysis by chi-square teste considering significant p<0.05.
Results:
Sixty-four patients were included, most of them females (56.3%), predominant age group between 26 and 55 years, of whom 25 required optimization, 23 remained in remission with the usual dose and interval, and 16 required switch; most of those who needed switch had hematological problems such as anemia and/or had already undergone surgical treatment for CD.
Conclusions:
Anemia and prior CD surgery have been linked to loss of anti-TNF response.
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