[Perioperative radiotherapy of bone and soft tissue tumors]

The goal of pre- and/or postoperative irradiation of soft tissue sarcoma combined with conservative surgery is to reduce the local failure rate comparable to that of radical surgery but with substantial less morbidity and loss of function; this is realized, so that local control and survival rates following combined therapy are comparable to those achieved by radical surgery alone. The high effect of fast neutrons is mentioned especially in large tumors. In osteosarcoma fast neutron therapy may give better chance for inactivation of tumor cells resistant against chemotherapy.