Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Skin transplantation or artificial skin replacement?].

A Berger1, J F Burke

  • 1Klinik für Plastische und Wiederherstellungschirurgie, Medizinischen Hochschule Hannover.

Langenbecks Archiv Fur Chirurgie
|January 1, 1987
PubMed
Summary

Closing large skin defects remains a challenge due to limited autologous skin availability. Current artificial skin substitutes, like the bovine collagen-based dermis, still require patient cells for complete skin coverage.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Diagnosis and therapy of peripheral nerve injuries. The "integrated therapy concept"].

Der Unfallchirurg·1999
Same author

Bone marrow transplantation for autoimmune diseases.

BMJ (Clinical research ed.)·1999
Same author

Diagnostic value of ultrasonography in patients with palpable mammographically noncalcified breast tumors.

Acta radiologica (Stockholm, Sweden : 1987)·1999
Same author

Variability in the interpretation of ultrasonography in patients with palpable noncalcified breast tumors.

Acta radiologica (Stockholm, Sweden : 1987)·1999
Same author

[Hypoglycemic coma of long duration].

Revue medicale de la Suisse romande·1999
Same author

[Endocarditis manifesting as a spondylodiscitis and psoas abscess].

Revue medicale de la Suisse romande·1999

Area of Science:

  • Biomaterials science
  • Regenerative medicine
  • Wound healing research

Context:

  • Large skin defect closure is a significant clinical challenge.
  • Autologous skin grafts are limited in availability.
  • Existing skin substitutes offer temporary solutions, not permanent closure.

Purpose:

  • To review the limitations of current skin substitutes for large defect closure.
  • To highlight the potential of artificial skin innovations.
  • To identify the need for a complete skin substitute without autologous material.

Summary:

  • The closure of extensive skin defects presents a persistent problem, primarily due to the limited availability of autologous skin.
  • Various skin substitutes have been developed, but they primarily serve as temporary coverings.
  • An artificial dermis composed of bovine collagen and chondroitin-6-sulfate offers a promising avenue, particularly for burn patients.
  • However, this artificial dermis still necessitates the use of autologous epithelial cells for complete skin regeneration, indicating that a fully autologous-free skin substitute is yet to be realized.

Impact:

  • Advances in artificial skin could alleviate donor site morbidity and improve outcomes for patients with extensive skin loss.
  • The development of a complete, off-the-shelf skin substitute would revolutionize the treatment of severe burns and chronic wounds.
  • Further research into bioengineering complete skin substitutes is crucial for addressing the global shortage of viable skin grafts.

Related Experiment Videos