Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Masonry Cavity Walls01:26

Masonry Cavity Walls

1.3K
Cavity walls feature a hollow space between the outer and inner wythes, connected only by corrosion-resistant metal ties. When water seeps through the outer wythe, it descends within this cavity, intercepted by flashing and eventually exiting through weep holes. To enhance moisture resistance, the inner wythe's cavity side often receives damp-proofing, doubling as an air barrier. The cavity can also house insulation to mitigate heat transfer.
Maintaining a clean cavity during construction...
1.3K
Structure of Cadherins01:25

Structure of Cadherins

4.2K
The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins”   is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This...
4.2K
Composite Masonry Walls01:18

Composite Masonry Walls

1.5K
Composite masonry walls combine multiple wythes of the same or different masonry materials to create a unified structure. These walls feature wythes that are bonded together either through mortar-filled collar joints, grouted spaces, or more commonly, with rigid metal ties and reinforcements, with the use of masonry header units being rare. Metal ties are preferred because they effectively minimize water penetration, as these walls primarily absorb moisture and then release it into the...
1.5K
Computed Tomography01:10

Computed Tomography

7.7K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
7.7K
Stress Concentrations01:24

Stress Concentrations

509
Stress concentration is when stress intensifies near discontinuities such as holes or abrupt cross-sectional changes in a structural member. This localized stress can often surpass the average stress within the member. The stress distribution in flat bars, either with a circular hole or varying widths connected by fillets, can be determined experimentally using a photoelastic method. The results are based on ratios of geometric parameters like the ratio of the hole's radius to the smaller...
509
Masonry Curtain Walls01:20

Masonry Curtain Walls

1.4K
Masonry curtain walls employ brick or stone veneers supported by the building's structure to form an external cladding system that is both aesthetically appealing and functional. These walls are erected through two principal techniques, first by traditional layering of masonry units and second by using prefabricated panels. Traditional construction relies on steel shelf angles attached to the spandrel beam for support, with high-bond mortars ensuring secure attachment of masonry veneer...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

bio.tools: an expanded web service for research software in the life sciences.

Nucleic acids research·2026
Same author

Foldify: Web Application for Protein Structure Prediction.

Journal of chemical information and modeling·2026
Same author

C-terminal long-QT type 1 R562S-Kv7.1 variant, the first variant in helix C impairing β-adrenergic response of the slow delayed rectifier K+ channel.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2026
Same author

ISBT Working Party on Information Technology Guideline on external electronic communication of transfusion traceability information.

Vox sanguinis·2026
Same author

MolMeDB RDF: transforming a relational database about biological membranes to the RDF format to increase interoperability.

Journal of cheminformatics·2026
Same author

PROPTIMUS LIVE: local constrained α-carbon optimization of proteins.

Nucleic acids research·2026
Same journal

Correction to 'New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress'.

Nucleic acids research·2026
Same journal

VeloRM: disentangling pre- and post-splicing RNA modification dynamics at single-cell resolution.

Nucleic acids research·2026
Same journal

Accessibility of telomeric overhangs to stabilizing small-molecule ligands.

Nucleic acids research·2026
Same journal

Multivalent interactions mediate SNAIL transcription factor stimulation of the nucleosome deacetylase activity of the CoREST complex.

Nucleic acids research·2026
Same journal

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions and transcription start sites.

Nucleic acids research·2026
Same journal

Correction to 'The Gene Ontology knowledgebase in 2026'.

Nucleic acids research·2026
See all related articles

Related Experiment Video

Updated: Nov 28, 2025

Enhancing Electrode Location Assessment in Cochlear Implantation via Computed Tomography Image Fusion
03:58

Enhancing Electrode Location Assessment in Cochlear Implantation via Computed Tomography Image Fusion

Published on: January 17, 2025

692

CATH: increased structural coverage of functional space.

Ian Sillitoe1, Nicola Bordin1, Natalie Dawson1

  • 1Institute of Structural and Molecular Biology, University College London, London WC1E 6BT, UK.

Nucleic Acids Research
|November 25, 2020
PubMed
Summary
This summary is machine-generated.

The CATH database now offers expanded protein structure and sequence data, enhancing functional annotations and providing new tools like CATH-FunVar for analyzing sequence variations. This update improves the understanding of protein families and their functions.

More Related Videos

Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance
08:12

Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance

Published on: September 5, 2018

16.4K
Non-fluoroscopic Catheter Tracking for Fluoroscopy Reduction in Interventional Electrophysiology
10:46

Non-fluoroscopic Catheter Tracking for Fluoroscopy Reduction in Interventional Electrophysiology

Published on: May 26, 2015

13.6K

Related Experiment Videos

Last Updated: Nov 28, 2025

Enhancing Electrode Location Assessment in Cochlear Implantation via Computed Tomography Image Fusion
03:58

Enhancing Electrode Location Assessment in Cochlear Implantation via Computed Tomography Image Fusion

Published on: January 17, 2025

692
Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance
08:12

Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance

Published on: September 5, 2018

16.4K
Non-fluoroscopic Catheter Tracking for Fluoroscopy Reduction in Interventional Electrophysiology
10:46

Non-fluoroscopic Catheter Tracking for Fluoroscopy Reduction in Interventional Electrophysiology

Published on: May 26, 2015

13.6K

Area of Science:

  • Structural bioinformatics
  • Protein domain classification

Background:

  • The CATH database classifies protein structures into evolutionary superfamilies, providing structural and functional annotations.
  • CATH offers two levels: CATH-B (daily snapshots) and CATH+ (derived data like predicted sequence domains and Functional Families/FunFams).

Purpose of the Study:

  • To present the latest CATH+ release (v4.3) with significantly increased data coverage and improved Functional Family (FunFam) generation.
  • To introduce CATH-FunVar web pages for analyzing protein sequence variations.
  • To showcase improved data integration with external resources.

Main Methods:

  • Expansion of structural and sequence data coverage in CATH+.
  • Re-engineering the FunFam generation pipeline to handle increased data.
  • Development of CATH-FunVar web pages for variation analysis.
  • Enhancement of cross-references to external databases (SCOP, InterPro, etc.).

Main Results:

  • CATH+ v4.3 includes 500,238 structural domains (+15%) and 151 million predicted sequence domains (+59%) across 5481 superfamilies.
  • FunFam generation captured three times more sequences, improving functional purity, information content, and structural coverage.
  • Structural annotations for Gene Ontology (GO) terms increased by 59%.
  • CATH-FunVar web pages and improved database links are now available.

Conclusions:

  • The CATH database continues to be a vital resource for protein structure and function annotation, with significant expansion in version 4.3.
  • Enhanced FunFam coverage and the introduction of CATH-FunVar provide deeper insights into protein sequence variations and functional sites.
  • Improved data integration enhances the utility of CATH for the broader research community.