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The wisdom trial is based on faulty reasoning and has major design and execution problems

Daniel B Kopans¹

¹Radiology, Harvard Medical School, 20 Manitoba Road, Waban, MA, 02468, USA. dkopans@verizon.net.

Breast Cancer Research and Treatment

|November 25, 2020

Abstract

Purpose:

To evaluate the design and plan of execution of the "WISDOM" trial.

Methods:

The rationale and reasoning behind the WISDOM Trial were reviewed and analyzed. The published parameters of the trial were reviewed.

Results:

The study is based on a failed understanding of the available data about breast cancer screening and is based on faulty assumptions, false reasoning, a scientifically unsupportable study design, ignoring advances in screening, a questionable endpoint, the likely lacking of power to answer the primary question, and support by insurance companies whose primary goal is almost certainly to reduce their costs.

Conclusion:

A major part of the premise is that there is a "debate" about the efficacy of screening. WISDOM ignores the fact that the "debate" has been manufactured and is not science-based. The results of the WISDOM Trial may be misleading.

Keywords:

Breast cancer Screening Screening trials

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