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Can Systemic Immune-Inflammation Index (SII) be a prognostic factor of Bell's palsy patients?
Abdullah Kınar1, Şahin Ulu2, Abdulkadir Bucak2
1Ear Nose and Throat Head and Neck Diseases, Afyonkarahisar State Hospital, Orhangazi Nedim Helvacıoğlu Blv. No:73, Afyonkarahisar, Turkey. abdullahkinar@gmail.com.
Objective:
Recent studies showed that the neutrophil-to-lymphocyte ratio (NLR) and that platelet-to-lymphocyte ratio (PLR) can be used as inflammatory markers in Bell's palsy. In this study, the aim is to investigate a novel inflammatory index, the Systemic Immune-Inflammation Index (SII), defined as SII = platelets × neutrophils/lymphocytes, in Bell's palsy patients.
Study Design:
Retrospective.
Setting:
Clinical research center.
Patients:
The study included 88 Bell's palsy patients and 50 healthy controls.
Interventions:
Patients diagnosed with Bell's palsy from 2010 to 2019 in a university hospital and an age- and sex-matched healthy control group were included in the study retrospectively. A complete blood count was performed for all participants. Magnetic resonance imaging was applied for Bell's palsy patients for the exclusion of other diagnoses.
Main Outcome Measures:
The CBC parameters were analyzed and hemoglobin, erythrocytes, leukocytes, neutrophils, lymphocytes, and platelet counts were measured. The PLR, NLR, and SII values were calculated with the formula.
Results:
The patient group had higher neutrophil counts and higher SII and NLR values than the control group (p < 0.05). Also, SII value is a prognostic factor in Bell's palsy in our study.
Conclusions:
Bell's palsy has an inflammatory component. The SII value can indicate an inflammatory condition in these patients. It may be used as a marker and prognostic indicator in Bell's palsy.
