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Updated: Nov 28, 2025

Monitoring PD-1-Blocking Antibodies Bound to T Cells Derived from a Drop of Peripheral Blood
Published on: February 5, 2020
[Immune-related adverse events of checkpoint inhibitors: an internist/general practitioner's point of view]
Christophe Cisarovsky1, Vanessa Kraege1, Michel Obeid2
1Service de médecine interne, Département de médecine interne, CHUV, 1011 Lausanne.
Abstract:
Immune checkpoint inhibitors have radically changed oncology by significantly improving prognosis and survival of many patients, even at an advanced or metastatic stage. Some patients undergoing immunotherapy develop adverse immune-related events, presenting a toxicity spectrum that can affect any organ, separately or simultaneously, with different intensities depending on the treatment used and patient characteristics. We hereby suggest a diagnostic and therapeutic approach that any internist, general practitioner or emergency doctor should have facing digestive, cardiac and pulmonary toxicities.
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