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An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation

Sarmistha Saha1, Brigitta Buttari1, Emiliano Panieri2

  • 1Department of Cardiovascular, Endocrine-Metabolic Diseases and Aging, Italian National Institute of Health, 00161 Rome, Italy.

Molecules (Basel, Switzerland)
|November 26, 2020
PubMed

Insights

The Nrf2 signaling pathway regulates antioxidant genes and inflammation. Modulating this pathway offers a new therapeutic strategy for inflammatory diseases.

Area of Science:

  • Molecular Biology
  • Immunology
  • Pharmacology

Background:

  • Inflammation is implicated in numerous diseases, driving the search for novel therapeutic targets.
  • The transcription factor Nrf2 is crucial for controlling antioxidant gene expression, which possesses anti-inflammatory properties.
  • Nrf2 and its regulator Keap1 maintain cellular redox balance and regulate inflammation.

Purpose of the Study:

  • To review the intricate relationship between Nrf2 signaling and inflammation.
  • To explore therapeutic strategies targeting the Nrf2 pathway for immune response modulation.

Main Methods:

  • Literature review focusing on Nrf2 signaling, antioxidant response element (ARE) system, and inflammatory pathways.
  • Analysis of recent studies connecting Nrf2 to inflammatory mediators, NF-κB pathway, and macrophage metabolism.

Main Results:

  • Nrf2 activation leads to the expression of antioxidant genes with anti-inflammatory effects.
  • The Nrf2/ARE system influences inflammatory mediators and the NF-κB pathway.
  • Nrf2 signaling impacts macrophage metabolism, suggesting a role in immune cell function.

Conclusions:

  • The Nrf2 pathway represents a promising target for developing new anti-inflammatory therapies.
  • Modulating Nrf2-dependent pathways could offer novel strategies for treating inflammatory conditions.
  • Targeting Nrf2 signaling may provide a new approach to modulate the immune response in disease.
Keywords:
Keap1Nrf2inflammationoxidative stresspolyphenols

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