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Risk stratification in heart failure with mild reduced ejection fraction
Damiano Magrì1, Giovanna Gallo1, Gianfranco Parati2,2
1Cardiology Unit, Department of Clinical and Molecular Medicine, Sapienza University of Rome, Sant'Andrea Hospital, Italy.
European Journal of Preventive Cardiology
|November 26, 2020
Summary
Cardiopulmonary exercise testing (CPET) aids in risk stratifying patients with heart failure with mid-range ejection fraction (HFmrEF). Specific CPET parameters, like peak oxygen uptake, identify high-risk individuals needing closer monitoring.
Area of Science:
- Cardiology
- Exercise Physiology
Background:
- Heart failure with mid-range ejection fraction (HFmrEF) is a significant and complex subgroup of heart failure.
- Accurate risk stratification and clinical phenotyping for HFmrEF remain challenging.
Purpose of the Study:
- To evaluate the utility of cardiopulmonary exercise testing (CPET) for risk stratification in HFmrEF patients.
- To identify specific CPET parameters associated with adverse outcomes in HFmrEF.
Main Methods:
- Analysis of a large cohort of recovered HFmrEF patients.
- Utilizing CPET-derived parameters, including peak oxygen uptake and ventilatory efficiency.
- Investigating the association between CPET parameters and cardiovascular mortality.
Main Results:
- Peak oxygen uptake was independently associated with cardiovascular mortality in HFmrEF.
- A combination of peak oxygen uptake (55% predicted max) and ventilatory efficiency (31) identified a high-risk HFmrEF subset.
Conclusions:
- CPET is a valuable tool for functional assessment in HFmrEF.
- CPET can identify high-risk HFmrEF patients who may benefit from closer follow-up and aggressive treatment.
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