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Related Concept Videos

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...

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Related Experiment Video

Updated: Jun 26, 2026

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis
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Published on: March 25, 2016

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Tattoo Granulomas With Uveitis.

Guiset Carvajal Bedoya1, Liron Caplan1,2, Karen L Christopher1

  • 1University of Colorado, Denver, CO, USA.

Journal of Investigative Medicine High Impact Case Reports
|November 26, 2020
PubMed
Summary
This summary is machine-generated.

Tattoo granulomas with uveitis (TAGU) can occur without systemic sarcoidosis. This condition, presenting as bilateral intraocular inflammation, often requires advanced immunosuppression for remission.

Keywords:
granulomapanuveitistattooingtumor necrosis factor-αuveitis

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Area of Science:

  • Ophthalmology
  • Immunology
  • Dermatology

Background:

  • Bilateral intraocular inflammation and tattoo granulomas are rarely reported.
  • The exact pathophysiology linking tattoos to granulomas and uveitis remains unclear, with theories suggesting links to sarcoidosis or delayed hypersensitivity.

Observation:

  • A patient with no prior sarcoidosis diagnosis developed bilateral panuveitis and tattoo changes consistent with tattoo granulomas with uveitis (TAGU).

Findings:

  • Initial treatment with topical and systemic steroids showed minimal improvement.
  • The patient achieved remission only after initiating steroid-sparing therapy with a tumor necrosis factor inhibitor.

Implications:

  • Tattoo granuloma with uveitis (TAGU) should be considered in patients with tattoos presenting with unexplained uveitis.
  • The increasing prevalence of tattoos necessitates awareness of potential ocular inflammatory complications.
  • Effective management may require advanced immunosuppressive agents beyond corticosteroids.