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Clinical and epidemiological features of heart-hand syndrome, an updated analysis in China

Yaobin Yin1, Jianguang Ji2,3, Junhui Zhao1

  • 1Department of Hand Surgery, Beijing Ji Shui Tan Hospital, Xin jie kou dong jie 31, Xi Cheng Qu, Beijing, 100035, China.

BMC Musculoskeletal Disorders
|November 26, 2020
PubMed

Insights

Heart-Hand Syndrome (HHS) affects over 12% of Chinese patients with congenital upper limb malformations. Thumb malformations are most common in HHS patients, who also show higher comorbidity rates.

Area of Science:

  • Cardiology
  • Orthopedics
  • Genetics

Background:

  • Congenital upper extremity malformations are common.
  • Heart-Hand Syndrome (HHS) is a known association.
  • Prevalence and features of HHS in China require investigation.

Purpose of the Study:

  • To determine the prevalence of Heart-Hand Syndrome (HHS) in Chinese patients with congenital upper limb malformations.
  • To explore the clinical and epidemiological characteristics of HHS in this population.

Main Methods:

  • Prospective recruitment of 1653 patients with congenital upper limb malformations from 2016-2019.
  • Review of medical records, including electrocardiogram (ECG) and echocardiogram data.
  • Analysis of demographic and clinical characteristics of patients with and without HHS.

Main Results:

  • 12.1% of patients (200/1653) exhibited abnormal ECG and/or echocardiogram findings, indicative of HHS.
  • Atrial septal defect was the most common cardiac anomaly (38.1%), and wave patterns the most common ECG abnormality (36.8%).
  • HHS patients had a higher comorbidity rate (11%) than non-HHS patients (6.9%), with thumb malformations being the most frequent upper extremity defect (60.5%).

Conclusions:

  • Heart-Hand Syndrome is prevalent in Chinese patients with congenital upper extremity malformations.
  • Thumb malformations are the most common hand defect associated with HHS.
  • HHS is more frequent in patients with multiple congenital malformations.
Abstract

Keywords:
ClassificationClinical epidemiologyCongenital malformationsHeart-hand syndrome (HHS)

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