Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Longitudinal Serum Metabolomic Signatures Related to Integrase Strand Transfer Inhibitors-Associated Weight Gain in Women with HIV Enrolled in the MACS/WIHS Combined Cohort Study.

The Journal of infectious diseases·2026
Same author

Fabrication of Microneedle Patches by Suspension Casting of Drugs in Organic Solvents.

Pharmaceutics·2026
Same author

High-resolution metabolomics of maternal polybrominated diphenyl ethers (PBDE) exposure and preterm birth in the Atlanta African American Maternal-Child Cohort.

Communications medicine·2026
Same author

Vision for Exposomics-Scale Investigation: A Heuristic for Exposure-Wide Association Studies (ExWAS).

Environmental science & technology·2026
Same author

Communicating Confidence in the Reliability of Micro- and Nanoplastic Identification in Human Health Studies.

Environment & health (Washington, D.C.)·2026
Same author

Untargeted metabolomic profiling of childhood asthma: An exploratory analysis of anthropogenic chemicals and the serum metabolome.

Environmental epidemiology (Philadelphia, Pa.)·2026
Same journal

Erratum for the Research Article "Guanosine diphosphate-mannose suppresses homologous recombination repair and potentiates antitumor immunity in triple-negative breast cancer".

Science translational medicine·2026
Same journal

CAR T cell therapy selectively depletes disease-driving mutant calreticulin cells in xenotransplants and human organoid models of myelofibrosis.

Science translational medicine·2026
Same journal

Bioresponsive microneedle stent provides anastomosis and postoperative adjuvant therapy in preclinical resectable intestinal diseases.

Science translational medicine·2026
Same journal

Alzheimer's disease proteome-wide association study implicates adaptive immunity and identifies risk genes LILRB1 and SIRPA.

Science translational medicine·2026
Same journal

KSHV-infected endothelial cells expand and up-regulate angiogenic pathways and CXCR4 in patient-derived Kaposi sarcoma models.

Science translational medicine·2026
Same journal

Hypoxia-driven T cell-macrophage-stromal cross-talk sustains fibrosis in preclinical models of cutaneous chronic graft-versus-host disease.

Science translational medicine·2026
See all related articles

Related Experiment Video

Updated: Nov 28, 2025

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

14.7K

Sampling interstitial fluid from human skin using a microneedle patch.

Pradnya P Samant1, Megan M Niedzwiecki2,3, Nicholas Raviele1

  • 1School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.

Science Translational Medicine
|November 26, 2020
PubMed
Summary
This summary is machine-generated.

A new microneedle patch allows minimally invasive collection of interstitial fluid (ISF) from skin. This method reveals ISF as a valuable source for continuous biomarker monitoring, complementing blood and urine analysis.

More Related Videos

Absorbent Microbiopsy Sampling and RNA Extraction for Minimally Invasive, Simultaneous Blood and Skin Analysis
06:18

Absorbent Microbiopsy Sampling and RNA Extraction for Minimally Invasive, Simultaneous Blood and Skin Analysis

Published on: February 21, 2019

10.3K
Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

3.0K

Related Experiment Videos

Last Updated: Nov 28, 2025

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

14.7K
Absorbent Microbiopsy Sampling and RNA Extraction for Minimally Invasive, Simultaneous Blood and Skin Analysis
06:18

Absorbent Microbiopsy Sampling and RNA Extraction for Minimally Invasive, Simultaneous Blood and Skin Analysis

Published on: February 21, 2019

10.3K
Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

3.0K

Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Dermatology

Background:

  • Tissue interstitial fluid (ISF) is an underutilized source of biomarkers.
  • Lack of simple collection methods has limited ISF research.
  • ISF analysis offers potential to complement blood and urine biomarkers.

Purpose of the Study:

  • To develop a minimally invasive microneedle-based method for ISF sampling.
  • To identify and compare biomarkers in ISF and plasma.
  • To assess the potential for continuous monitoring of biomarkers in ISF.

Main Methods:

  • Developed a microneedle patch for creating skin micropores.
  • Applied mild suction to collect ISF from human participants.
  • Utilized mass spectrometry for biomarker identification and comparison with plasma.

Main Results:

  • Successfully sampled ISF from 21 participants using the microneedle patch.
  • Identified clinically relevant biomarkers in ISF, some distinct from plasma.
  • Demonstrated similar pharmacokinetics of caffeine and pharmacodynamics of glucose in ISF and plasma.

Conclusions:

  • Microneedle patch enables minimally invasive dermal ISF collection.
  • Human ISF is a viable source for biomarker discovery and continuous monitoring.
  • ISF analysis holds promise for future clinical applications and research.