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Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
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Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

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The association between indices of blood pressure waveforms (PTC1 and PTC2) and incident heart failure

Lyndia C Brumback1, Leah I B Andrews1, David R Jacobs2

  • 1Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington.

Journal of Hypertension
|November 26, 2020
PubMed

Insights

Higher radial artery pulse waveform PTC2 is linked to a lower risk of developing heart failure, particularly heart failure with reduced ejection fraction. This finding suggests PTC2 may be a novel indicator for heart failure risk.

Area of Science:

  • Cardiovascular Physiology
  • Biomedical Engineering
  • Clinical Cardiology

Background:

  • The radial artery pulse waveform offers continuous pressure data, exceeding traditional systolic and diastolic measures.
  • New indices, PTC1 and PTC2, derived from a Windkessel model, correlate with arterial compliance and predict cardiovascular diseases.
  • The association of PTC1 and PTC2 with heart failure risk remained uninvestigated.

Purpose of the Study:

  • To investigate the association between baseline radial artery pulse waveform indices (PTC1 and PTC2) and the incidence of heart failure.
  • To determine if these indices predict heart failure risk in a diverse adult population free of cardiovascular disease and heart failure.

Main Methods:

  • A cohort of 6229 adults, free of cardiovascular disease and heart failure, were analyzed.
  • Baseline radial artery pulse waveform indices (PTC1 and PTC2) were measured between 2000-2002.
  • Incident heart failure events were tracked over a median of 15.7 years, with adjustments for traditional risk factors.

Main Results:

  • Higher PTC2 was significantly associated with a reduced risk of overall heart failure (HR=0.73).
  • Increased PTC2 showed a strong inverse relationship with heart failure with reduced ejection fraction (HR=0.67).
  • No significant association was found between PTC1 and heart failure, nor between PTC2 and heart failure with preserved ejection fraction.

Conclusions:

  • The PTC2 index derived from the radial artery pulse waveform may serve as a novel phenotype for predicting heart failure.
  • PTC2 appears particularly relevant for identifying individuals at lower risk of heart failure with reduced ejection fraction.
  • Further research is warranted to explore the clinical utility of PTC2 in cardiovascular risk assessment.
Abstract

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