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Relationships between diuretic-related hyperuricemia and cardiovascular events: data from the URic acid Right for

Alessandro Maloberti1,2, Michele Bombelli2,3, Rita Facchetti2

  • 1Cardiology IV, 'A. De Gasperis' Department, Ospedale Niguarda Ca' Granda.

Journal of Hypertension
|November 26, 2020
PubMed

Insights

Diuretic-related hyperuricemia (high uric acid) poses a similar cardiovascular event and mortality risk as hyperuricemia without diuretic use. This finding is crucial for understanding cardiovascular health in patients taking diuretics.

Area of Science:

  • Cardiology
  • Nephrology
  • Pharmacology

Background:

  • Hyperuricemia is a known risk factor for cardiovascular events.
  • The specific impact of diuretic-induced hyperuricemia on cardiovascular outcomes remains under-researched.

Purpose of the Study:

  • To investigate the relationship between diuretic-related hyperuricemia and cardiovascular events.
  • To compare the cardiovascular risk associated with hyperuricemia in patients using diuretics versus those not using them.

Main Methods:

  • The URic acid Right for heArt Health (URRAH) study, a nationwide observational cohort study in Italy.
  • 17,747 individuals were analyzed, with follow-up averaging 122.3 months.
  • Patients were grouped by diuretic use and serum uric acid (SUA) levels (median 4.8 mg/dl); outcomes included all-cause death and cardiovascular events.

Main Results:

  • 17.2% of participants used diuretics, and 58% of these had SUA above the median.
  • In multivariate analysis, individuals with hyperuricemia and diuretic use showed a similar risk for cardiovascular events and death compared to a reference group with hyperuricemia but no diuretic use.
  • No significant difference in risk was observed between the groups.

Conclusions:

  • Diuretic-related hyperuricemia is associated with a comparable risk of cardiovascular events and all-cause mortality as hyperuricemia in non-users.
  • These findings highlight the importance of monitoring uric acid levels in patients on diuretic therapy.
  • Further research may inform management strategies for cardiovascular risk in this population.
Abstract

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