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Current understanding of CREPT and p15RS, carboxy-terminal domain (CTD)-interacting proteins, in human cancers

Mengdi Li1, Danhui Ma1, Zhijie Chang2

  • 1State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, 100084, Beijing, China.

Oncogene
|November 26, 2020
PubMed

Insights

Regulation of nuclear pre-mRNA-domain-containing (RPRD) proteins CREPT and p15RS have opposing roles in cell proliferation and cancer. Understanding their functions in transcription and DNA repair could lead to new cancer therapies.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Gene Regulation

Background:

  • CREPT and p15RS are conserved RPRD proteins that bind the C-terminal domain (CTD) of RNA polymerase II (RNAPII).
  • These proteins share a yeast orthologue, Rtt103, but exhibit opposing functions in human cells.
  • Aberrant expression of CREPT and p15RS is implicated in various cancers.

Purpose of the Study:

  • To review recent studies on the biological roles of CREPT and p15RS.
  • To elucidate the molecular mechanisms underlying their functions in gene transcription and DNA repair.
  • To explore their potential as targets for cancer diagnosis and therapy.

Main Methods:

  • Literature review of recent studies on CREPT and p15RS.
  • Analysis of molecular mechanisms involving RNAPII interaction.
  • Investigation of roles in DNA damage repair pathways.

Main Results:

  • CREPT promotes cell cycle progression and tumor growth, while p15RS inhibits proliferation.
  • Both proteins regulate gene transcription through interaction with RNAPII.
  • CREPT plays a significant role in DNA damage repair processes.

Conclusions:

  • CREPT and p15RS have distinct and opposing functions in cell proliferation and tumorigenesis.
  • Their mechanisms of action involve regulating gene transcription and DNA stability.
  • Further understanding of CREPT and p15RS functions may yield novel strategies for cancer treatment.

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