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Chronic ischaemic heart disease and rivaroxaban: which patients derive the greatest benefit?

Leonardo Bolognese1, Massimo Felici1

  • 1Dipartimento Cardio-neuro-vascolare, Azienda Sudest Toscana,Italy.

European Heart Journal Supplements : Journal of the European Society of Cardiology
|November 26, 2020
PubMed

Insights

Patients with cardiovascular disease can reduce risks of heart attack, stroke, and death. Adding low-dose rivaroxaban to aspirin therapy significantly lowers these major adverse cardiovascular events in stable coronary artery disease.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Pharmacology

Background:

  • Established cardiovascular (CV) disease patients face risks of recurrent events despite optimal treatment.
  • Platelet inhibition is key in preventing new CV events.
  • Anticoagulant therapy for atheromatous disease prevention was previously underutilized.

Purpose of the Study:

  • To review the results of the Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease (COMPASS) trial.
  • To assess the impact of rivaroxaban plus aspirin on secondary prevention in stable coronary artery disease.

Main Methods:

  • The COMPASS trial investigated the efficacy of rivaroxaban 2.5 mg twice daily plus low-dose aspirin.
  • The study focused on patients with stable coronary artery disease.

Main Results:

  • Rivaroxaban plus low-dose aspirin significantly reduced the composite endpoint of stroke, heart attack, and death.
  • The combination therapy demonstrated a promising effect on secondary prevention.

Conclusions:

  • The COMPASS trial provides significant findings for secondary prevention in stable cardiovascular disease.
  • This regimen may alter current clinical practice for managing patients with established atheromatous disease.

Keywords:
Chronic coronary syndromeRivaroxaban

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