Examples of adverse effects after biological therapy
Ewa Hadas1, Andrzej Bozek1, Anna Cudak1
1Clinical Department of Internal Disease, Dermatology and Allergology in Zabrze, Medical University of Silesia in Katowice, Poland.
Postepy Dermatologii I Alergologii
|November 26, 2020
Summary
Biological drugs like adalimumab and ustekinumab offer new psoriasis treatment options. While effective, these advanced therapies can cause adverse reactions such as urticaria and erythema multiforme in some patients.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Psoriasis is a common, chronic skin disease with an unclear cause, increasingly linked to immunological factors.
- Biological drugs, including adalimumab and ustekinumab, are now used to treat psoriasis, especially for resistant cases or those with adverse reactions to standard treatments.
Purpose of the Study:
- To present case studies of patients undergoing biological treatment for psoriasis.
- To highlight observed adverse reactions associated with biological therapies for psoriasis.
Main Methods:
- Retrospective case series of four patients treated with biological agents for psoriasis.
- Clinical observation and documentation of adverse events, including hypersensitivity reactions and serological changes.
Main Results:
- Observed adverse reactions included acute urticaria, erythema multiforme-like lesions, and elevated antinuclear antibody titers.
- These adverse events did not pose a life-threatening risk to the patients.
- The therapeutic benefits of the biological drugs were significant despite the observed side effects.
Conclusions:
- Biological treatments for psoriasis, such as adalimumab and ustekinumab, demonstrate significant therapeutic value.
- Patients may experience hypersensitivity reactions and other adverse events, necessitating careful monitoring.
- The benefits of biological therapy often outweigh the risks of manageable adverse reactions in psoriasis management.
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