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The Relationship between Depression Symptoms and Severity of Coronary Artery Disease in Patients Undergoing

Arsalan Salari1, Asieh Ashouri1, Arezoo Javadzadeh Moghtader1

  • 1Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

Iranian Journal of Psychiatry
|November 26, 2020
PubMed

Insights

This study found no link between depression symptoms and the severity of coronary artery disease (CAD) in patients undergoing angiography. However, depression was associated with angina, regardless of CAD severity.

Area of Science:

  • Cardiology
  • Psychiatry
  • Epidemiology

Background:

  • Cardiovascular diseases (CVDs) are a leading global cause of mortality.
  • Depression is recognized as a contributing factor to the development of CVDs, including coronary artery stenosis.
  • Understanding the relationship between depression and coronary artery disease (CAD) severity is crucial for patient management.

Purpose of the Study:

  • To investigate the association between depression symptoms and the severity of coronary artery disease (CAD) in patients scheduled for angiography.
  • To determine if depression influences the extent of coronary artery involvement or the overall severity of CAD.
  • To explore the independent relationship between depression and angina symptoms.

Main Methods:

  • A prospective, cross-sectional study involving 401 patients undergoing angiography.
  • Data collection included demographic information, medical history, and the Beck Depression Questionnaire II (BDI-II).
  • Statistical analyses, including Spearman correlation and Mann-Whitney U regression, were employed to analyze the data.

Main Results:

  • After adjusting for age, sex, and diabetes history, no significant relationship was found between depression symptoms and the frequency of vessel involvement or CAD severity.
  • The severity of depression symptoms also showed no significant correlation with the extent or severity of CAD.
  • Depression was found to be independently associated with angina symptoms, irrespective of CAD severity.

Conclusions:

  • Depression symptoms are not significantly correlated with the severity or number of involved vessels in coronary artery disease (CAD) among patients undergoing angiography.
  • Depression is linked to angina, independent of the severity of underlying CAD.
  • The cross-sectional design and single-time point measurement of depression may limit the ability to establish a causal link or track the long-term impact of depression on atherosclerosis progression.

Keywords:
Coronary AngiographyDepression SymptomSeverity of Coronary Artery Disease* Stenosis

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