Related Experiment Video

Updated: Nov 28, 2025

An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses
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An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses

Published on: November 28, 2010

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Immunotherapies in ovarian cancer

Elena García-Martínez1, J Alejandro Pérez-Fidalgo2

  • 1Department of Medical Oncology, Hospital Universitario Morales Meseguer, Instituto Murciano de Investigación Biosanitaria (IMIB), Grupo Español de Investigación en Cáncer de Ovario (GEICO), Murcia, Spain.

EJC Supplements : EJC : Official Journal of EORTC, European Organization for Research and Treatment of Cancer ... [Et Al.]
|November 26, 2020
PubMed

Insights

New ovarian cancer therapies are needed. This review explores immunotherapy strategies for immune desert, inflamed, and immune-excluded ovarian tumors, highlighting the need for better understanding of the tumor microenvironment.

Area of Science:

  • Gynecologic Oncology
  • Immunotherapy
  • Tumor Microenvironment

Background:

  • Ovarian cancer is a leading cause of gynecologic cancer mortality.
  • Tumor-infiltrating lymphocytes correlate with improved prognosis in ovarian cancer.
  • Immunotherapy is not yet a standard treatment for ovarian cancer.

Purpose of the Study:

  • To review current and emerging immunotherapy strategies for ovarian cancer.
  • To categorize strategies based on tumor immune microenvironment (immune desert, inflamed, excluded).
  • To emphasize the need for enhanced understanding of tumor biology and immunology.

Main Methods:

  • Literature review of preclinical and clinical studies.
  • Categorization of ovarian tumors based on immune infiltration.
  • Synthesis of data on immunotherapy approaches for different tumor types.

Main Results:

  • Various immunotherapy strategies are under investigation for ovarian cancer.
  • Effectiveness varies depending on the tumor's immune profile.
  • Specific approaches are being developed for immune desert, inflamed, and immune-excluded tumors.

Conclusions:

  • Further research into ovarian cancer biology and the immune microenvironment is crucial.
  • Tailoring immunotherapy based on tumor immune characteristics is essential for clinical success.
  • Developing novel immunotherapy strategies holds promise for improving patient outcomes.
Keywords:
ImmunotherapyOvarian cancer

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