Related Experiment Video

Updated: Nov 28, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.5K

Plasma lipidomic profiling identifies a novel complex lipid signature associated with ischemic stroke in chronic

Farsad Afshinnia1, Adil Jadoon1, Thekkelnaycke M Rajendiran2,3

  • 1University of Michigan, Department of Internal Medicine-Nephrology, Ann Arbor, MI.

Journal of Translational Science
|November 26, 2020
PubMed

Insights

Plasma lipid alterations, including phosphatidylcholines (PCs) and phosphatidylethanolamines (PEs), are associated with stroke in patients with chronic kidney disease (CKD). These lipid changes may serve as novel risk factors for stroke.

Area of Science:

  • Biochemistry
  • Metabolomics
  • Nephrology

Background:

  • Dyslipidemia is a known contributor to ischemic stroke.
  • However, the specific plasma lipidomic profiles associated with stroke in individuals with chronic kidney disease (CKD) remain understudied.

Purpose of the Study:

  • To identify and characterize plasma lipid alterations linked to stroke in patients with CKD.
  • To explore the potential of these lipid changes as risk factors for stroke in this population.

Main Methods:

  • A cross-sectional study involving 214 participants from the Clinical Phenotyping and Resource Biobank Core (CPROBE).
  • Plasma samples were analyzed using liquid chromatography/mass spectrometry-based untargeted lipidomics.
  • Statistical analyses included t-tests with false discovery rate adjustment and logistic regression to identify independent lipid predictors of stroke.

Main Results:

  • Over 330 lipid compounds were identified, with significant overrepresentation of phosphatidylcholines (PCs) and phosphatidylethanolamines (PEs) in patients with stroke.
  • Elevated levels of palmitate and PC38:4 were independently associated with a higher risk of stroke.
  • Trends toward increased abundance of PCs, PEs, plasmenyl-PEs (pPEs), and sphingomyelins were observed in stroke patients.

Conclusions:

  • Differential regulation of specific lipids, including palmitate, PCs, and PEs, is observed in CKD patients with a history of stroke.
  • These lipid alterations may represent a novel, unrecognized risk factor for stroke in CKD.
  • Further research is needed to determine the temporal relationship and potential for risk stratification and modification.
Abstract

Keywords:
chronic kidney diseasefatty acidslipidsmass spectrometrystroke

More Related Videos

Using a Chemical Biopsy for Graft Quality Assessment05:00

Using a Chemical Biopsy for Graft Quality Assessment

Published on: June 17, 2020

5.4K
Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies05:30

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

Published on: January 31, 2025

853

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
370
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
372
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
156
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
223
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
448
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
587