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Systemic photoprotective agents.

H S Black1

  • 1Photobiology Laboratory, Veterans Administration Medical Center, Houston, Texas.

Photo-Dermatology
|August 1, 1987
PubMed
Summary
This summary is machine-generated.

Systemic photoprotectants offer an alternative to topical agents for preventing actinic damage. Future research should focus on agents enhancing natural defenses like melanization for effective photoprotection.

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Area of Science:

  • Dermatology and photobiology, focusing on skin damage prevention.

Background:

  • Topical agents for actinic damage have limitations.
  • Systemic photoprotectants face challenges in metabolism and toxicity.
  • Existing agents treat specific photosensitive diseases, not general photoprotection.

Purpose of the Study:

  • To review systemic agents for actinic damage prevention.
  • To identify promising strategies for future photoprotectant development.

Main Methods:

  • Review of existing literature on systemic photoprotective agents.
  • Analysis of agent efficacy, toxicity, and mechanisms of action.

Main Results:

  • Some agents (antimalarials, psoralens, carotenoids) treat specific conditions but lack general photoprotection.

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  • Certain agents inhibit UV carcinogenesis (butylated hydroxytoluene, carotenoids), while others potentiate it (8-methoxypsoralen).
  • No reviewed agents are suitable for general photoprotection currently.

    • Conclusions:

    • Agents enhancing natural defense mechanisms (melanization, antiradical activity) show the most promise.
    • Modest enhancement of natural defenses can significantly reduce actinic damage, especially skin cancer.
    • Systemic photoprotection remains a crucial goal for preventing actinic damage.