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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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Mutant p53 in Cancer Progression and Targeted Therapies

Gaoyang Zhu1, Chaoyun Pan2, Jin-Xin Bei3

  • 1Postdoctoral Research Center, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, China.

Frontiers in Oncology
|November 26, 2020
PubMed

Insights

Mutant TP53 proteins drive cancer by losing tumor suppression and gaining oncogenic functions. This review explores targeting these mutant p53 gain-of-functions with emerging therapies like gene editing and immunotherapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Genetics

Background:

  • TP53 is the most frequently mutated tumor suppressor gene in human cancers.
  • Most TP53 mutations result in full-length mutant p53 proteins with altered functions.
  • Mutant p53 proteins exhibit both loss of tumor suppressive functions and acquisition of oncogenic gain-of-functions (GOF).

Purpose of the Study:

  • To review recent advances in understanding the oncogenic GOF of mutant p53 (Mutp53).
  • To summarize potential therapeutic strategies targeting Mutp53 in human cancers.

Main Methods:

  • Literature review of recent advances in Mutp53 research.
  • Discussion of current clinical trials and emerging therapeutic strategies.

Main Results:

  • Mutp53 proteins promote tumorigenesis through GOF.
  • Several therapeutic strategies are under investigation, including gene editing, peptide-mediated restoration, and immunotherapy.

Conclusions:

  • Targeting Mutp53 GOF represents a promising therapeutic avenue for human cancers.
  • Emerging strategies like CRISPR/Cas9, peptide restoration, and immunotherapies offer new hope for treating TP53-mutated cancers.
Keywords:
drug resistancegain-of-functionmutant p53 proteintargeted therapytumorigenesis

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