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A Structural View on ESCRT-Mediated Abscission.

Péter Horváth1, Thomas Müller-Reichert1

  • 1Experimental Center, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Frontiers in Cell and Developmental Biology
|November 26, 2020
PubMed
Summary
This summary is machine-generated.

The endosomal sorting complex required for transport (ESCRT) machinery is crucial for cell division. This review highlights ESCRT

Keywords:
3D reconstructionabscissioncytokinesiselectron microscopyelectron tomographyendosomal sorting complexes required for transport (ESCRT)membranesmicrotubules

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • The endosomal sorting complex required for transport (ESCRT) machinery regulates membrane remodeling events.
  • Key ESCRT functions include multivesicular body (MVB) formation, viral budding, and cytokinesis.
  • Abscission, the final step of cell division, involves the physical separation of daughter cells.

Purpose of the Study:

  • To review the role of ESCRT components in the abscission process.
  • To focus on the spatio-temporal organization of molecular machinery in mammalian cells during abscission.

Main Methods:

  • Review of existing scientific literature.
  • Analysis of data from in vitro experiments.
  • Analysis of data from in vivo experiments.

Main Results:

  • ESCRT components play a critical role in the abscission stage of cytokinesis.
  • Understanding the precise molecular mechanisms and timing of ESCRT involvement is essential.
  • The review synthesizes current knowledge on ESCRT function in mammalian cell abscission.

Conclusions:

  • ESCRT machinery is indispensable for successful cell division.
  • Further research is needed to fully elucidate the complex spatio-temporal regulation of ESCRT during abscission.
  • This review provides a foundation for future investigations into ESCRT-mediated abscission.