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Related Concept Videos

Glaucoma: Overview01:25

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
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Related Experiment Video

Updated: Nov 28, 2025

Doppler Optical Coherence Tomography of Retinal Circulation
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Published on: September 18, 2012

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Optical coherence tomography angiography in glaucoma.

Masoud Aghsaei Fard1, Robert Ritch2

  • 1Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran.

Annals of Translational Medicine
|November 26, 2020
PubMed
Summary
This summary is machine-generated.

Optical coherence tomography angiography (OCTA) reveals vascular changes in glaucoma, including reduced optic nerve and retinal vessel density. These changes may precede visual field damage, aiding in early glaucoma detection and progression monitoring.

Keywords:
OCT angiographychoroidglaucomaglaucoma progressionmaculamicrovasculatureoptic nerve head (ONH)

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Glaucoma Research

Background:

  • Glaucoma diagnosis and progression monitoring rely on assessing optic nerve and retinal nerve fiber layer (RNFL) thickness.
  • Optical coherence tomography angiography (OCTA) offers advanced visualization of ocular vasculature.

Purpose of the Study:

  • To evaluate the role of OCTA in assessing vascular changes in glaucoma.
  • To correlate vascular density in different ocular regions with glaucoma severity and progression.

Main Methods:

  • Utilized optical coherence tomography angiography (OCTA) to assess vasculature in the optic nerve, peripapillary retina, macula, and peripapillary choroid.
  • Correlated vessel density measurements with glaucoma severity and visual field defects.

Main Results:

  • Decreased perfusion in the optic nerve's pre-laminar layer correlates with glaucoma severity.
  • Reduced peripapillary superficial retinal vessel density aids in glaucoma diagnosis and progression detection, similar to RNFL thickness.
  • Vascular changes may precede detectable visual field damage.
  • Macular ganglion cell (MGC) thickness and macular vessel density show reductions in glaucoma.
  • Increased prevalence of choroidal microvasculature dropout observed in glaucomatous eyes.

Conclusions:

  • OCTA is a valuable tool for detecting and monitoring glaucoma-related vascular changes.
  • Vascular alterations in the optic nerve, retina, and choroid are significant indicators in glaucoma.
  • Further research is needed to determine if reduced vessel density is a primary or secondary event in glaucoma pathogenesis.