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Related Experiment Video

Updated: Nov 28, 2025

Establishment and Genetic Manipulation of Murine Hepatocyte Organoids
14:54

Establishment and Genetic Manipulation of Murine Hepatocyte Organoids

Published on: February 12, 2022

5.3K

Organoids to model liver disease.

Sandro Nuciforo1, Markus H Heim1,2

  • 1Department of Biomedicine, University Hospital Basel, University of Basel, CH-4031 Basel, Switzerland.

JHEP Reports : Innovation in Hepatology
|November 26, 2020
PubMed
Summary

Organoid models offer a revolutionary 3D in vitro approach to studying liver diseases. These advanced models mimic in vivo tissues, advancing personalized medicine and drug discovery for liver conditions.

Keywords:
3D culturesA1AT, alpha-1 antitrypsinALD, alcohol-related liver diseaseCCA, cholangiocarcinomaCFTR, cystic fibrosis transmembrane conductance regulatorCHC, combined hepato-cholangiocarcinomaCLD, chronic liver diseaseCTLN1, citrullinemia type 1Chol-orgs, cholangiocyte organoidsDisease modellingEGF, epidermal growth factorER, endoplasmic reticulumESCs, embryonic stem cellsFFAs, free fatty acidsHCC, hepatocellular carcinomaHUVEC, human umbilical vein endothelial cellsHep-orgs, hepatocyte organoidsIL-, interleukin-Liver diseaseMSC, mesenchymal stem cellNAFLD, non-alcoholic fatty liver diseaseOrganoidsPDO, patient-derived organoidPDX, patient-derived xenograftPHH, primary human hepatocytePSC, primary sclerosing cholangitisPersonalised medicinePreclinical modelsiPSC, induced pluripotent stem cell

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Area of Science:

  • Cell Biology
  • Biomedical Research
  • Regenerative Medicine

Background:

  • Organoid models represent a significant advancement over traditional cell cultures.
  • They are 3D physiological in vitro structures mimicking in vivo tissues.
  • Organoids recapitulate the morphological and functional features of native tissues.

Purpose of the Study:

  • To review current liver organoid models for studying liver disease.
  • To highlight the advantages of organoids in biomedical research.
  • To explore applications in personalized medicine and drug discovery.

Main Methods:

  • Discussion of current liver organoid models.
  • Analysis of organoid utility in disease modeling.
  • Exploration of organoid applications in regenerative medicine.

Main Results:

  • Liver organoids are valuable tools for modeling diverse liver diseases.
  • Organoid models offer insights into personalized medicine and drug discovery.
  • These models present significant advantages over conventional cell culture methods.

Conclusions:

  • Liver organoids are pivotal in advancing the study of liver diseases.
  • Organoid technology revolutionizes biomedical research and therapeutic strategies.
  • Patient-derived organoids pave the way for personalized liver therapies.