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Updated: Nov 28, 2025

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER
Published on: June 23, 2012
Somatic variant analysis of linked-reads sequencing data with Lancet
Rajeeva Musunuri1, Kanika Arora1, André Corvelo1
1Computational Biology Lab, New York Genome Center, New York, NY 10013, USA.
Summary:
We present a new version of the popular somatic variant caller, Lancet, that supports the analysis of linked-reads sequencing data. By seamlessly integrating barcodes and haplotype read assignments within the colored De Bruijn graph local-assembly framework, Lancet computes a barcode-aware coverage and identifies variants that disagree with the local haplotype structure.
Availability And Implementation:
Lancet is implemented in C++ and available for academic and non-commercial research purposes as an open-source package at https://github.com/nygenome/lancet.
Supplementary Information:
Supplementary data are available at Bioinformatics online.
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