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A Green, Economic "Switch-On" Sensor for Cefixime Analysis Based on Black Soya Bean Carbon Quantum Dots
Yuecheng Zhang1, Jingyuan Wang1, Wenbo Wu1
1Yan'an University, College of Chemistry and Chemical Engineering, Key Laboratory of Analytical Technology and Detection of Yan'an, Yan'an 716000, Shaanxi Province, P. R. China.
Journal of AOAC International
|November 26, 2020
Summary
A new "switch-on" sensor using carbon quantum dots (CQDs) offers a sensitive and practical method for detecting the antibiotic cefixime. This cost-effective approach provides reliable cefixime analysis in various samples.
Area of Science:
- Analytical Chemistry
- Materials Science
- Biotechnology
Background:
- Cefixime is a vital third-generation cephalosporin antibiotic for treating bacterial infections.
- Current cefixime analysis methods are often costly and complex.
- A need exists for sensitive, practical cefixime detection techniques.
Purpose of the Study:
- Develop a sensitive and robust "switch-on" sensor for cefixime detection.
- Utilize carbon quantum dots (CQDs) for enhanced sensor performance.
Main Methods:
- Synthesized fluorescent carbon quantum dots (CQDs) from black soya beans using a green method.
- Exploited Ce(IV)-induced fluorescence quenching of CQDs.
- Demonstrated cefixime's ability to restore fluorescence by interrupting electron transfer.
Main Results:
- Achieved high sensitivity in cefixime detection.
- Established a low detection limit of 169 nM for cefixime.
- Demonstrated successful cefixime detection in pharmaceutical tablets and biological samples.
Conclusions:
- The developed CQD-based sensor is low-cost, simple, stable, selective, and highly sensitive.
- This method shows significant potential for drug analysis, biological process research, and clinical applications.
