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Design and Synthesis of Fused Pyridine Building Blocks for Automated Library Generation
Helena Mora-Radó1, Werngard Czechtizky2,3, María Méndez2
1Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK.
Chemmedchem
|November 26, 2020
Abstract:
We demonstrate that a diboration-electrocyclization sequence provides access to a range of pyridine-fused, small-molecule boronic ester building blocks, and that these are amenable to high-throughput synthesis leading to biaryl and ether-linked compound libraries. Moreover, the implementation of an integrated physicochemical and ADME profiling workflow allows accelerated design of novel lead compounds for application in drug-discovery projects.

