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Related Concept Videos

Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

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Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
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Updated: Nov 28, 2025

Author Spotlight: Understanding and Detecting Environmental Antimicrobial Resistance by Combining Culture-Based Techniques and Genomics
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Modelling how antimicrobial resistance spreads between wards.

Tjibbe Donker1

  • 1Institute for Infection Prevention and Hospital Epidemiology, University Medical Center Freiburg, Freiburg, Germany.

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|November 26, 2020
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Summary
This summary is machine-generated.

Hospital patient transfers and high antibiotic use significantly worsen the spread of drug-resistant bacterial infections. Reducing these factors is crucial for infection control.

Keywords:
E. coliKlebsiella pneumoniaeMRSAantibiotic stewardshipantibioticsantimicrobial resistanceecologyinfection controlinfectious diseasemicrobiology

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Area of Science:

  • Infectious Diseases
  • Hospital Epidemiology
  • Antimicrobial Resistance

Background:

  • Hospital-acquired infections (HAIs) pose a significant threat to patient safety.
  • The rise of antimicrobial resistance (AMR) complicates treatment and increases mortality.
  • Patient movement and antibiotic stewardship are key factors in HAI transmission.

Purpose of the Study:

  • To investigate the correlation between patient ward transfers and the incidence of hospital-acquired infections.
  • To assess the impact of high-level antibiotic prescription on the prevalence of resistant bacterial strains.
  • To identify modifiable factors influencing the spread of antimicrobial resistance in healthcare settings.

Main Methods:

  • Retrospective analysis of patient transfer logs and antibiotic prescription data.
  • Microbiological surveillance to identify bacterial pathogens and their resistance profiles.
  • Statistical modeling to quantify the association between patient mobility, antibiotic use, and infection rates.

Main Results:

  • A significant positive association was found between the frequency of inter-ward patient transfers and the incidence of bacterial infections.
  • Hospitals with higher rates of broad-spectrum antibiotic prescribing showed a marked increase in multidrug-resistant organisms (MDROs).
  • Specific patient populations and ward types were identified as high-risk for transmission.

Conclusions:

  • Inter-ward patient movement is a critical driver for the dissemination of resistant bacteria within hospitals.
  • Judicious antibiotic prescribing and optimized patient flow are essential strategies to combat AMR.
  • Implementing enhanced infection control protocols targeting patient transfers and antibiotic stewardship is recommended.