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Related Experiment Videos

August Krogh: Muscle capillary function and oxygen delivery.

David C Poole1, Yutaka Kano2, Shunsaku Koga3

  • 1Departments of Kinesiology and Anatomy and Physiology, Kansas State University Manhattan, Kansas 66506, USA.

Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
|November 26, 2020
PubMed
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August Krogh

Area of Science:

  • Physiology
  • Microcirculation
  • Exercise Science

Background:

  • The capillary bed is essential for oxygen and substrate delivery to cells.
  • Skeletal muscle, the largest organ, has extensive capillaries crucial for metabolic homeostasis, especially during exercise.
  • August Krogh's 1919 work revolutionized understanding of capillaries, viewing them as active vessels recruited during exercise.

Purpose of the Study:

  • To review the historical impact of August Krogh's foundational work on muscle microcirculation.
  • To highlight the critical role of capillary beds in oxygen and substrate transport to skeletal muscle.
  • To emphasize the importance of microcirculation in skeletal muscle plasticity and disease.

Main Methods:

  • Historical review of August Krogh's 1919 publications.
Keywords:
Capillary hemodynamicsExerciseO(2) uptake kineticsRed blood cell flux

Related Experiment Videos

  • Analysis of Krogh's conflation of muscle capillary function with mathematical models of oxygen diffusion.
  • Synthesis of current understanding of microcirculation's role in physiology and pathology.

    • Main Results:

    • Krogh's papers established capillaries as active, recruited vessels during exercise, not passive conduits.
    • His work founded the field of muscle microcirculation and highlighted oxygen diffusing capacity.
    • The study underscores the significance of microcirculation for skeletal muscle adaptation and disease mechanisms.

    Conclusions:

    • August Krogh's research fundamentally changed the understanding of capillary function in skeletal muscle.
    • Comprehending microcirculation is key to understanding exercise training adaptations and pathologies like heart failure and diabetes.
    • Krogh's legacy is foundational to current research in exercise physiology and metabolic disease.