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Updated: Nov 28, 2025
Lipidomics and Transcriptomics in Neurological Diseases
Published on: March 18, 2022
Serum Neuropeptide Y Level is Associated with Post-Ischemic Stroke Epilepsy
Nuan Wang1, Dongxing Wang2, Hao Zhou3
1Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou City, 215004, China; Department of Neurology, Affiliated Hospital of China University of Mining and Technology, Xuzhou City, 221116, China.
Low serum neuropeptide Y (NPY) is a significant risk factor for post-ischemic stroke epilepsy (PISE). Monitoring NPY levels could aid in preventing and treating PISE.
Area of Science:
- Neurology
- Neuroscience
- Biochemistry
Background:
- Post-ischemic stroke epilepsy (PISE) is a frequent complication following stroke.
- Identifying risk factors for PISE is crucial for effective management.
Purpose of the Study:
- To determine the risk factors associated with post-ischemic stroke epilepsy (PISE).
- To investigate the role of serum neuropeptide Y (NPY) levels in PISE.
Main Methods:
- A case-control study involving 78 PISE patients and 86 non-PISE patients.
- Collection and analysis of clinical data and serum neuropeptide Y (NPY) levels.
Main Results:
- Low serum NPY levels were significantly associated with an increased risk of PISE.
- Serum NPY demonstrated high diagnostic accuracy (AUC 0.910) with a cutoff of 90 ng/ml.
- Higher serum NPY levels correlated with a reduced incidence of PISE, particularly in the highest tertile (≥105 ng/ml).
Conclusions:
- Serum NPY is an independent risk factor for PISE.
- Targeting serum NPY levels presents a potential strategy for PISE prevention and treatment.
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