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The effectiveness of early anticoagulant treatment in Covid-19 patients

Yakup Arslan1, Gulden Yilmaz2, Deniz Dogan1

  • 1Department of Pulmonology, Gulhane Education and Research Hospital, University of Health Sciences, Ankara, Turkey.

Phlebology
|November 27, 2020
PubMed

Insights

Early anticoagulant treatment with Low Molecular Weight Heparin (LMWH) in hospitalized COVID-19 patients showed improved outcomes. LMWH use was associated with reduced intensive care unit transfers and shorter hospital stays, suggesting clinical benefits.

Area of Science:

  • Medical Research
  • Infectious Diseases
  • Pharmacology

Background:

  • COVID-19 is a rapidly spreading infectious disease.
  • Thrombosis can worsen COVID-19 outcomes.
  • Early intervention is crucial for managing severe infections.

Purpose of the Study:

  • To evaluate the impact of early anticoagulant therapy in hospitalized COVID-19 patients.
  • To compare outcomes between patients treated with and without Low Molecular Weight Heparin (LMWH).

Main Methods:

  • Retrospective comparative cohort study of 413 hospitalized COVID-19 patients.
  • Treatment groups: LMWH (n=187) vs. no LMWH (n=226).
  • Data collected before and after an updated treatment guide in April 2020.

Main Results:

  • LMWH-treated patients had higher d-dimer and platelet counts.
  • LMWH-untreated patients showed increased inflammatory markers (ferritin, IL-6, procalcitonin).
  • LMWH-treated patients had more comorbidities but fewer ICU transfers and shorter hospital stays.

Conclusions:

  • Early anticoagulant treatment with LMWH may enhance clinical outcomes in COVID-19.
  • Higher doses of LMWH could potentially shorten hospital stays.
  • LMWH treatment appears beneficial for hospitalized COVID-19 patients.
Abstract

Keywords:
Covid-19 diseaseanticoagulationheparininfectious diseasethrombosis

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